Dear Department of Health and Social Care,
Gangrene and limb loss are complications resulting from vasopressor administration during the management pf septic shock. Vasopressors are used to combat acute hypotension where the loss of BP can lead to multi-organ failure and death. Vasopressors constrict the arteries in the limbs and prolonged use leads to disseminated intravascular coagulation (DIC), where retained blood in the vessels clots and impairs the return flow, once vasopressor use is withdrawn. Ichaemia, gangrene and limb salvage/amputation then result.
1. How many patients underwent limb salvage/amputations following sepsis management in the NHS during 2016, 2017, 2018?
2. How many patients underwent limb salvage/amputations following sepsis management in the NHS for the first six months of 2019
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Dear Mr Russell,
Please find attached the Department of Health and Social Care's response
to your recent FOI request. (our ref: FOI-1193692)
Freedom of Information team
Department of Health and Social Care
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