Dear Gloucestershire Health and Care NHS Foundation Trust,

I would like to please request the following information:

The purpose of these questions is to understand the variability of treatment within your trust and in context to the rest of the country.

Q1. In the past 3 months (or the latest 3 months data you have available), how many melanoma patients were treated with:
• Bevacizumab (Avastin)
• Dacarbazine (DTIC)
• Trametinib (Mekinist)
• Dabrafenib (Tafinlar)
• Ipilimumab (Yervoy)
• Vemurafenib (Zelboraf)
• Nivolumab (Opdivo)
• Nivolumab + Ipilimumab (Opdivo + Yervoy)
• Pembrolizumab (Keytruda)
• Vemurafenib + cobimetinib (Zelboraf + Cotellic)
• Dabrafenib + Trametinib (Tafinlar + Mekinist)
• Braftovi (encorafenib) in combination with Mektovi (binimetinib) for BRAF V600 patients
• Other active systemic anti-cancer therapy [please state]
• Palliative care only

Q2. In the past 3 months (or the latest 3 months data you have available), how many metastatic melanoma patients were treated with the following:
• Ipilimumab
• Ipilimumab AND Nivolumab
• Nivolumab
• Pembrolizumab
• Dabrafenib AND Trametinib
• Any Other Targeted Therapy (Dabrafenib /Encorafenib AND Binimetinib /Trametinib /Vemurafenib /Vemurafenib AND Cobimetinib)
• Other active systemic anti-cancer therapy
• Palliative care only

Thank you for answering these questions.

Yours faithfully,

Ed Fryer