Clozapine and Coroners

name removed 23 Oct 2012 (Account suspended) made this Freedom of Information request to National Patient Safety Agency

The request was refused by National Patient Safety Agency.

From: name removed 23 Oct 2012 (Account suspended)

1 January 2012

1 January 2012

Dear National Patient Safety Agency,

I have been reading many articles about anti-psychotic medications
and in particular Haloperidol, Olanzapine, Amisulpride and
Clozapine.

Today I found some links on the internet regarding Clozapine:

http://topnews.net.nz/content/28820-inve...

http://www.stuff.co.nz/national/health/1...

http://www.health.vic.gov.au/chiefpsychi...

http://www.thisishullandeastriding.co.uk...

I would like to know

1.] Has the NPSA has been investigating Coroners' reports where
antipsychotics, especially Clozapine, have been stated to be
involved in anyone's death?

2.] Has the NPSA liaised with any other regulatory bodies and/or
government bodies/government agencies/Parliament/EU
Parliament/European Medicines Agency/European Ombudsman/PHSO

a] regarding the specific safety of these antipsychotics, and,

b]where people are being FORCED to take these antipsychotics by
doctors who are treating patients under Section 2 or 3 of the
Mental Health Act?

3.] How many people who have died after being on Clozapine had
consented to Clozapine treatment?

4.] How many people who have died after being on Clozapine had NOT
consented to Clozapine treatment?

5.] How many people who were involuntary patients were FORCED to
take Clozapine treatment against their will, and then have suffered
serious side-effects, and / or death?

6.] How many patients are currently enrolled on the National
Clozaril Register who have been monitored for heart problems and
found to have Sinus Tachycardia and Right Atrial Enlargement by ECG
BEFORE they were given Clozapine?

7.] How many patients are currently enrolled on the National
Clozaril Register who have been monitored for heart problems by ECG
AFTER they were given Clozapine and found to have Sinus Tachycardia
and Right Atrial Enlargement?

I am very concerned lest patients with heart problems are continued
on the Clozapine programme and feel that anyone with Sinus
Tachycardia and/or Right Atrial Enlargement, as found on ECG,
should

a] not be enrolled on the Clozapine Programme in any event and this
should be recorded on the National Register

b] should be taken off the Clozapine Programme if this is then
found

c] doctors should not assume the safety of Clozapine in patients
with pre-existing Sinus Tachycardia and /or Right Atrial
Enlargement and should NOT give Clozapine to such patients as they
have a pre-existing heart condition

8] I wish to know how many patients have been CONTINUED on
Clozapine when doctors have stated that the Sinus Tachycardia and /
or Right Atrial Enlargement were already present and THEREFORE
Clozapine is not contraindicated, whereas I beg to differ.

9] Is there to be a national moratorium on Clozapine safety in the
light of known deaths connected with Clozapine worldwide?

Thank you very much for your help

Happy New Year 2012

Yours sincerely,

[first name removed] [last name removed]

Link to this

From: name removed 23 Oct 2012 (Account suspended)

9 January 2012

Dear National Patient Safety Agency,

I wrote on 1 January 2011 via WhatDoTheyKnow website to request
information under Freedom of Information 2000.

May I ask you to acknowledge my FOI please? Maybe you do not have
an automated response so that you possibly missed my application.

I would be most grateful if you can now look at my application on
http://www.whatdotheyknow.com if you have not received my original
FOI.

Thank you very much for your help,

Yours sincerely,

[first name removed] [last name removed]

Link to this

From: Michael Wilbur
National Patient Safety Agency

10 January 2012

Dear [first name removed],

Thank you for your email detailing a request for information, under the FOI Act, received by us on 3 January 2012.

We shall arrange for a reply to be sent to you within 20 working days of receipt of your request.

Many thanks,

Michael Wilbur

Michael Wilbur | Divisional Business Manager
Patient Safety Division
NHS National Patient Safety Agency
4-8 Maple Street, London, W1T 5HD
www.npsa.nhs.uk

show quoted sections

Link to this

From: name removed 23 Oct 2012 (Account suspended)

10 January 2012

Dear Michael,

Thank you very much for your reply, and I look forward to receiving
the data in due course via the charity website
http://www.whatdotheyknow.com .

With best wishes,

[first name removed]

Link to this

From: Sarndrah Horsfall
National Patient Safety Agency

13 January 2012


Attachment 2012 01 12 FOI R.last name removed.pdf
788K Download View as HTML


Dear Ms [last name removed]

 

Please find letter attached in response to your FOIA request.

 

Yours sincerely

 

Sarndrah Horsfall | Chief Executive

National Patient Safety Agency

Switchboard +44 (0)20 7927 9500 | Fax +44 (0)20 7927 9501

 

4-8 Maple Street, London, W1T 5HD

Web: [1]www.npsa.nhs.uk 

P  Help save paper - do you need to print this email?

 

show quoted sections

Link to this

From: name removed 23 Oct 2012 (Account suspended)

13 January 2012

Dear Ms Horsfall, National Patient Safety Agency,

Thank you very much for your response to my FOI Request and
indicating that the NPSA does not hold much data in relation to my
FOI Request except for
explaining:

'The NPSA has liaised with the Prescribing Observatory for Mental
Health(POMH-UK) as part of their on-going assessment of the British
National Formulary (BNF) 4.2 anti – psychotic drugs - "drugs used
in psychosis and related disorders".'

and

'9. Is there to be a national moratorium on Clozapine safety in the
light of known deaths connected with Clozapine worldwide?

We are not aware of this.'

These two points are of crucial relevance, I maintain, to the
protection and prevention of incidents and I would like to know
SPECIFICALLY what exact liasing the NPSA has done with the
Prescribing Observatory for Mental Health (POMH-UK) as part of
'their on-going
assessment of the British National Formulary (BNF) 4.2 anti –
psychotic drugs - "drugs used in psychosis and related disorders".'

This means that the NPSA clearly have information regarding
antipsychotic drugs, including Clozapine which is deemed to be one
of the drugs most in need of very close monitoring on account of
its known toxicity.

Therefore, I ask the NPSA to hold an internal review of my request
as I believe that there must be a lot of information you can give
me, please.

Thank you very much for your help,

Yours sincerely,

[first name removed] [last name removed]

Link to this

From: name removed 23 Oct 2012 (Account suspended)

13 January 2012

Dear National Patient Safety Agency,

Please pass this on to the person who conducts Freedom of
Information reviews.

I am writing to request an internal review of National Patient
Safety Agency's handling of my FOI request 'Clozapine and
Coroners'.

A full history of my FOI request and all correspondence is
available on the Internet at this address:
http://www.whatdotheyknow.com/request/cl...

Yours sincerely,

[first name removed] [last name removed]

Link to this

From: Michael Wilbur
National Patient Safety Agency

13 January 2012

Dear Ms [last name removed],

Thank you for your message.

We have passed this information for a second opinion and have confirmed that we do not hold the information you have requested.

Kind regards,

Michael

Michael Wilbur

show quoted sections

Link to this

From: name removed 23 Oct 2012 (Account suspended)

13 January 2012

Dear National Patient Safety Agency,

Thank you for seeking a second opinion, but I return to the fact
that you yourself stated that the NPSA had LIAISED WITH THE POMH,
and it is THIS that I maintain must mean that the NPSA does indeed
hold information otherwise how could they liaise?

And what were the findings of the liaison between NPSA and POMH?

Please pass this on to the person who conducts Freedom of
Information reviews.

I am writing to request an internal review of National Patient
Safety Agency's handling of my FOI request 'Clozapine and
Coroners'.

A full history of my FOI request and all correspondence is
available on the Internet at this address:
http://www.whatdotheyknow.com/request/cl...

Yours sincerely,

[first name removed] [last name removed]

Link to this

From: Kumba Jaiteh
National Patient Safety Agency

16 January 2012

Dear [first name removed]

Thank you for your FOI request, this has been passed onto my colleague.

Kind regards

Kumba Jaiteh on behalf of Enquiry Line

show quoted sections

Link to this

From: name removed 23 Oct 2012 (Account suspended)

17 January 2012

Dear Kumba,

Thank you very much for your kind help and I look forward to
hearing from you presently.

With best wishes,

[first name removed]

[first name removed] [last name removed]

Link to this

From: Sarndrah Horsfall
National Patient Safety Agency

9 February 2012


Attachment 2012 01 17 FOI Review last name removed.pdf
206K Download View as HTML


Dear Ms [last name removed]

 

Please find letter attached in response to your request for an internal
review of your FOIA request.

 

Yours sincerely

 

Sarndrah Horsfall | Chief Executive 

National Patient Safety Agency

Switchboard +44 (0)20 7927 9500 | Fax +44 (0)20 7927 9501

 

4-8 Maple Street, London, W1T 5HD

Web: [1]www.npsa.nhs.uk 

P  Help save paper - do you need to print this email?

 

show quoted sections

Link to this

From: name removed 23 Oct 2012 (Account suspended)

9 February 2012

Dear Ms Horsfall,

May I request a further internal review of the internal review
being the need to produce the data you mention within your response
but has not been made available because only you possess it and
therefore it is not available to the public for public access.

I am most grateful to you for the Internal Review which has indeed
provided me with more details.

There are, however, pieces of data which are not available by
internet - and I would appreciate it if you could publish these
either as an email attachment or as standard text inside your
response as I believe these to be crucial to understanding.

After all, if you possess it, and it is not otherwise available
then it passes the FOI test for data access, and I specifically
request all the data which is mentioned but which is NOT publicaly
available via your internet links.

I look forward to seeing the text of the data.

Thank you very much,

Yours sincerely,

[first name removed] [last name removed]

Campaigner for Liberty, Truth and Justice

Link to this

From: Sarndrah Horsfall
National Patient Safety Agency

17 February 2012


Attachment 2012 02 16 FOI R R.last name removed.pdf
143K Download View as HTML


Dear Ms [last name removed]

 

Please find letter attached in response to your request for an internal
review of our response to your FOIA request.

 

Yours sincerely

 

Sarndrah Horsfall | Chief Executive 

National Patient Safety Agency

Switchboard +44 (0)20 7927 9500 | Fax +44 (0)20 7927 9501

 

4-8 Maple Street, London, W1T 5HD

Web: [1]www.npsa.nhs.uk 

P  Help save paper - do you need to print this email?

 

show quoted sections

Link to this

From: name removed 23 Oct 2012 (Account suspended)

17 February 2012

17 February 2012
Dear Ms Horsfall,

Thank you,

Yours sincerely,

[first name removed] [last name removed]

Campaigner for legal reform, liberty, truth and justice

Link to this

From: name removed 23 Oct 2012 (Account suspended)

6 April 2012

6 April 2012

Please pass this on to the person who conducts Freedom of
Information reviews. I request that my entire correspondence be
reviewed by the National Patient Safety Agency re Clozapine and
Coroners

Dear National Patient Safety Agency,
Mr Lansley Secretary of State for Health,
Mr Clarke Lord Chancellor Secretary of State for Justice,
Mr Starmer, QC, Director of Public Prosecutions,
Crown Prosecution Service,
HMIC,
Mr Garnier Solicitor General,
HMCTS, including Coroners Courts
Mr Grieve, QC,Attorney General,
Mrs May Home Secretary,
Mr Turner MP for the Isle of Wight,
Information Commissioner,

I am writing to request an internal review of National Patient
Safety Agency's handling of my FOI request 'Clozapine and
Coroners'.

I have made previous requests for internal review but am
dissatisfied with the responses from the National Patient Safety
Agency after I found a specific document of CDN Isotopes where a
named person has signed a document in February 2012 in which it is
stated that Clozapine is a "known carcinogen".

That now begs a number of very serious questions about the handling
of my Freedom of Information Request regarding Clozapine and
Coroners.

How much is known by the British Government and its arm's length
agencies and quangos and ministerial departments about specific
TOXIC substances administered to people in the name of "health"?

I am at a loss to understand this.

I wish this to be investigated fully as this is surely in the
public interest.

It is tantamount to doctors prescribing tobacco as a health cure
whereas it is a known carcinogen and each packet of cigarettes sold
has a stark warning - smoking kills - on the outside of the box.

Yet people who are administered Clozapine might be unaware of the
dangers if Government DOES NOT DISCLOSE what they know about
Clozapine.

For how else can a person make an INFORMED CHOICE and INFORMED
DECISION?

Or is it just so convenient, perhaps, that some of the people
prescribed Clozapine literally have NO CHOICE in the matter because
they are deemed to be Sectionable and are Sectioned under Section 3
of the Mental Health Act 1983/2007?

I declare an interest in that a person very dear to me is one such
person and I am TERRIFIED of the longer-term consequences of this
drug administration, and, as such I am lobbying hard to find out
what is actually KNOWN about Clozapine.

Do we have a potential "Thalidomide" on our hands?

A full history of my FOI request and all correspondence is
available on the Internet at this address:
http://www.whatdotheyknow.com/request/cl...

Yours sincerely,

[first name removed] [last name removed]

Campaigner for legal reform, liberty, truth and justice

Link to this

From: name removed 23 Oct 2012 (Account suspended)

6 April 2012

6 April 2012

Dear National Patient Safety Agency, Mr Lansley Secretary of State
for Health, Mr Cameron Prime Minister of Great Britain and Northern
Ireland, Cabinet Office, Mr Turner MP for the Isle of Wight,

IS CLOZAPINE DANGEROUS?

WOULD YOU INGEST IT YOURSELF?

WOULD YOU GIVE IT TO YOUR FAMILY?

JUST HOW TOXIC IS CLOZAPINE?

WHY DO YOU PRESCRIBE A KNOWN CARCINOGEN AS A MEDICINE?

National Poisons Information Service commissoned by the Health
Protection Agency [first name removed] [last name removed] made
this Freedom of Information request to Health Protection Agency

The request was refused by Health Protection Agency.
From: [first name removed] [last name removed]

3 January 2012
Dear Health Protection Agency,

National Poisons Information Service commissoned by the Health
Protection Agency

I have found a reference to:

"Poisons Information in the UK

TOXBASE is the clinical toxicology database of the UK National
Poisons Information Service (NPIS), the department of Health
approved, and Health Protection Agency commissioned, national UK
service that provides expert advice on all aspects of acute
poisoning"

Unfortunately no public access details are provided, but the
webpage does state:

"As well as providing TOBASE, the UK NPIS also offers a 24 hour
national telephone information line ... which provides clinical
staff with case specific advice on more complex cases"

This particular webpage - TOXBASE Users update: Dec 2006 ISSN
1752-0649 - does make specific reference to both Zaponex and
Clozapine.

I was unaware that these antipsychotic drugs were considered as
poisons and/or toxic, as they are regulated drugs widely prescribed
across the world.

That being the case, what are these specific toxicology reports on
both Zaponex and Clozapine? Have there been any updates on these
drugs as well? Under Freedom of Information 2000 I request the HPA
to provide the details known to be in existence but unavailable to
non-clinical professionals.

As the general public are unable to contact this service, I would
be most grateful if these specific drugs monographs/reports could
be provided by whatdotheyknow charity website.

Thank you very much for your help

Yours sincerely,

[first name removed] [last name removed]

Link to this
From: Freedom Of Information
Health Protection Agency

4 January 2012
Dear Ms [last name removed],

The Freedom of Information team acknowledges your request for
information.

You will receive a response within 20 working days.

Kind regards,

Neville

Please reply to [Health Protection Agency request email]

show quoted sections

Link to this
From: [first name removed] [last name removed]

28 January 2012
Dear Neville,

Thank you very much for letting me know that I will be receiving
the response within the 20 working days timeframe.

I therefore look forward to receiving your response on Monday, 31
January 2012.

With my thanks and best wishes,

[first name removed]

[first name removed] [last name removed]

Campaigner for Liberty, Truth and Justice

Link to this
From: Freedom Of Information
Health Protection Agency

30 January 2012

--------------------------------------------------------------------------------

Case ref 001 toxicology reports on zaponex and clozapine.pdf
56K Download View as HTML

--------------------------------------------------------------------------------

Dear Ms [last name removed]

Please find attached the Health Protection Agency's response to
your request for information.

Feel free to contact me if you require further clarification.

Kind regards

Freedom of Information Officer

show quoted sections

Link to this
From: [first name removed] [last name removed]

30 January 2012
Dear Health Protection Agency,

Please pass this on to the person who conducts Freedom of
Information reviews.

I am writing to request an internal review of Health Protection
Agency's handling of my FOI request 'National Poisons Information
Service commissoned by the Health Protection Agency'.

I am grateful to you for replying but find that my FOI Request for
information has barely been addressed by your response.

I do note however that it is admitted that Clozapine IS ON THE
TOXBASE and is classified as a toxic substance.

Therefore, I believe it to be very much in the public interest to
have THE FULL REPORTS on Zaponex or Clozapine that I have
requested.

To use the Section 21 of the FOIA as the rationale to prevent the
public from KNOWING what is potentially dangerous is very wicked in
my opinion.

People's lives are thereby being put at potential risk by
withholding of such data.

The arrogance of the HPA in determining that very few people -
their chosen few - should be the sole initiates into drugs which
countless numbers of clinicians use all the time to treat
unsuspecting patients beggars belief.

Where is the SAFEGUARDING OF THE PUBLIC?

For you are now deeming that only SOME people must be ALLOWED
access to these reports.

This is surely a nightmare and should be taken up in Parliament
urgently.

How many doctors are registered in UK who regularly prescribe drugs
about which there ARE secret toxic reports done on these drugs of
which they ARE DISALLOWED FROM ACCESSING?

I now fear that doctors are routinely being scapegoated by a
litigious society in which the patients will complain that their
doctors gave them poisonous drugs AND DID NOT WARN THEM.

And I believe that you SHOULD and MUST make ALL THESE REPORTS
PUBLICLY ACCESSIBLE ONLINE SO THAT EVERYONE CAN READ THEM.

For if a patient reads something and is worried, then that patient
can approach their GP and ask for clarification.

And it is also the prescription of drugs "off label" and doctors
not being fully aware of the drugs and their toxicity levels that
makes me request this urgent Internal Review.

The Coroner's Decision published in December 2011 regarding
Catherine Bell linked her death to Clozapine.

I want to know why it is that the Clozaril national reporting
programme is solely concerned with blood testing for
agranulocytosis and nothing else has to be reported, according to
the MHRA. WHY NOT?

That is why I am very alarmed that doctors are NOT having to do
produce frequent ECGs alongside blood testing for agranulocytosis.
According to the MHRA the CLOZARIL PROGRAMME only assesses the
white blood cells NOT the heart.

Yet it is the heart that is ALSO a major worry.

How serious is a heart condition to be for Clozapine NOT to be
prescribed? NICE nor MHRA do not specify the precise conditions.

I wish to know if it is actually safe for:

a] a person with a regular frequent and clinically recorded record
of almost daily sinus tachycardia to be given Clozapine at all

b] a person with regular frequent and clinically recorded record of
almost daily sinus tachycardia AND ECG recording of Sinus
Tachycardia AND Right Atrial Enlargement to be given Clozapine at
all

c] a person with regular frequent and clinically recorded record of
sinus tachycardia medicated with Bisoprolol to reduce the heartbeat
rate AND Right Atrial Enlargement to be CONTINUED on Clozapine at
all

I have asked NICE specifically about Clozapine and Sinus
Tachycardia and Right Atrial Enlargement but they say they have not
any information on this specific condition. Why not? They are
specifically a national regulator on the safety and efficacy of
medicines.

I have asked MHRA specifically about Clozapine and Sinus
Tachycardia and Right Atrial Enlargement but they have stated that
a serious heart condition needs caution and have hitherto avoided
giving me a straightforward answer to my perfectly straightforward
question.

Clearly you have knowledge which you are suppressing, as you admit
yourself, and I believe that you owe it to me to explain precisely
what is and what is not regarded as a CONTRAINDICATION FOR
CLOZAPINE IN ANY EVENT.

Thank you very much for your help. This could help many people to
get the truth about their condition - mental health is a secret
that must be unlocked and not done behind closed doors.

Yours sincerely

[first name removed] [last name removed]

Campaingner for Liberty, Truth and Justice

From: [first name removed] [last name removed]

3 January 2012
Dear Health Protection Agency,

National Poisons Information Service commissoned by the Health
Protection Agency

I have found a reference to:

"Poisons Information in the UK

TOXBASE is the clinical toxicology database of the UK National
Poisons Information Service (NPIS), the department of Health
approved, and Health Protection Agency commissioned, national UK
service that provides expert advice on all aspects of acute
poisoning"

Unfortunately no public access details are provided, but the
webpage does state:

"As well as providing TOBASE, the UK NPIS also offers a 24 hour
national telephone information line ... which provides clinical
staff with case specific advice on more complex cases"

This particular webpage - TOXBASE Users update: Dec 2006 ISSN
1752-0649 - does make specific reference to both Zaponex and
Clozapine.

I was unaware that these antipsychotic drugs were considered as
poisons and/or toxic, as they are regulated drugs widely prescribed
across the world.

That being the case, what are these specific toxicology reports on
both Zaponex and Clozapine? Have there been any updates on these
drugs as well? Under Freedom of Information 2000 I request the HPA
to provide the details known to be in existence but unavailable to
non-clinical professionals.

As the general public are unable to contact this service, I would
be most grateful if these specific drugs monographs/reports could
be provided by whatdotheyknow charity website.

Thank you very much for your help

Yours sincerely,

[first name removed] [last name removed]

Link to this
From: Freedom Of Information
Health Protection Agency

4 January 2012
Dear Ms [last name removed],

The Freedom of Information team acknowledges your request for
information.

You will receive a response within 20 working days.

Kind regards,

Neville

Please reply to [Health Protection Agency request email]

show quoted sections

Link to this
From: [first name removed] [last name removed]

28 January 2012
Dear Neville,

Thank you very much for letting me know that I will be receiving
the response within the 20 working days timeframe.

I therefore look forward to receiving your response on Monday, 31
January 2012.

With my thanks and best wishes,

[first name removed]

[first name removed] [last name removed]

Campaigner for Liberty, Truth and Justice

Link to this
From: Freedom Of Information
Health Protection Agency

30 January 2012

--------------------------------------------------------------------------------

Case ref 001 toxicology reports on zaponex and clozapine.pdf
56K Download View as HTML

--------------------------------------------------------------------------------

Dear Ms [last name removed]

Please find attached the Health Protection Agency's response to
your request for information.

Feel free to contact me if you require further clarification.

Kind regards

Freedom of Information Officer

show quoted sections

Freedom of Information request 'National Poisons Information
Service commissoned by the Health Protection Agency'.
By email

Ref: 12/01/03/nc/001
Health Protection Agency

Public Information Access

61 Colindale Avenue
London
[email address]
NW9 5EQ

Tel +44 (0)20 8327 6920

Fax +44 (0)20 8327 6633

www.hpa.org.uk

Email: [Health Protection Agency request email]

30 January 2012

Dear Ms [last name removed]
Re: Toxicology reports on Zaponex and Clozapine

Thank you for your email dated 3 January 2012 regarding the
toxicology reports on Zaponex and Clozapine. In accordance with
section 1 (1) (a) of the Freedom of Information Act 2000, I confirm
that the Health Protection Agency (HPA) does hold some of the
information you have requested. Please see our response to your
questions below.

I was unaware that these antipsychotic drugs were considered as
poisons and/or toxic, as they are regulated drugs widely prescribed
across the world. That being the case, what are these specific
toxicology reports on both Zaponex and Clozapine? Have there been
any updates on these drugs as well?

Under Freedom of Information 2000 I request the HPA to provide the
details known to be in existence but unavailable to nonclinical
professionals.

As the general public are unable to contact this service, I would
be most grateful if these specific drugs monographs/reports could
be provided by whatdotheyknow charity website.

A point of clarification is that any medication taken in excess of
the recommended dosage can be poisonous/ toxic. Medication taken in
combination with other medications can be toxic/ poisonous.
Furthermore, the consumption of alcohol with medication often has a
potential adverse health effect which may include poisoning of the
individual.

All prescribed medication comes with accompanying inserts which
contain information about the medication and any known possible
adverse health effects.
Accordingly, the toxicity of the specific medications you mention
are available to you. Please be advised that much of the
information contained in the insert is the same as the information
held on TOXBASE. Therefore, in accordance with the section 21-
information reasonably accessible to applicant exemption, we
consider the requested information is reasonably accessible.

--------------------------------------------------------------------------------

The role of National Poisons Information Service (NPIS) is mainly
to provide advice to medical carers (doctors and nurses) of people
in accident and emergency and hospital. NPIS staff have developed
TOXBASE for this purpose but as the information covers all possible
clinical risks including those which are very rare, this
information is written for medical staff and scientists by medical
staff and scientists and is therefore highly technical and open to
misinterpretation by the lay reader.

If you are concerned about a health related matter we would advise
that you contact your GP/specialist or pharmacist.

I hope you have found this information helpful. If you have any
queries regarding the information that has been supplied to you,
please refer them in the first instance to myself. If you are
dissatisfied with this response and would like a copy of the HPA
complaints procedure then please contact Mr George Stafford,
Complaints Manager at: Health Protection Agency, 61 Colindale
Avenue, London NW9 5EQ.

Please note that you have the right to an independent review by the
Information Commissioner’s Office if a complaint cannot be resolved
through the HPA complaints procedure. The Information
Commissioner’s Office can be contacted by writing to Information
Commissioner’s Office, Wycliffe House, Water Lane, Wilmslow,
Cheshire SK9 5AF.

Yours sincerely,

Leigh Hopkins
Freedom of Information Officer
Health Protection Agency

[Health Protection Agency request email]

A full history of my FOI request and all correspondence is
available on the Internet at this address:
http://www.whatdotheyknow.com/request/na...

Yours faithfully,

[first name removed] [last name removed]

Link to this
From: Freedom Of Information
Health Protection Agency

31 January 2012
Dear Ms [last name removed]

The Freedom of Information Team acknowledges your request for
Internal
Review.

You will receive a response as soon as possible.

Kind Regards

Freedom of Information Officer

Please reply to [Health Protection Agency request email]

show quoted sections

Link to this
From: [first name removed] [last name removed]

1 February 2012
Dear Freedom Of Information,

Thank you very much for acknowledging my Request for Internal
Review. I look forward to receiving your response in due course.

I believe that this is a matter of grave importance as there are
people who are being FORCIBLY medicated against their will with
this drug and both they and their relatives are being PREVENTED
from KNOWING what is actually KNOWN of this drug and its potential
toxicity.

In the name of TRANSPARENCY IN PUBLIC LIFE, I charge you to give me
the data that is KNOWN about Clozapine as I believe there is a
major political angle as regards the use of this particular drug.

The death of Catherine Bell - as per the Coroner's Decision in
December 2011 reported in the media - must not be allowed to be
forgotten.

The PUBLIC need answers so as to see if future tragedies may be
averted. The more that the public are given information, the
better-informed we are to give consent to treatment - AND to
CHALLENGE TREATMENT AND NOT TO GIVE CONSENT.

It must NOT be the preserve of a few people who are "initiates" -
as that way madness lies, I aver.

Yours sincerely,

[first name removed] [last name removed]
Campaigner for Liberty, Truth and Justice

Link to this
From: Freedom Of Information
Health Protection Agency

24 February 2012

--------------------------------------------------------------------------------

Internal review National poisions information service.pdf
25K Download View as HTML

--------------------------------------------------------------------------------

<<Internal review - National poisions information service.pdf>>
Dear Ms [last name removed]

Please find attached the Health Protection Agency's internal review
response to your request for information. Please feel free to
contact me
if you require further clarification.

Kind regards

Gloria Akinyemi

show quoted sections

Link to this
From: [first name removed] [last name removed]

25 February 2012
25 February 2012

Dear Mr Stafford, Health Protection Agency, Mr Turner MP for the
Isle of Wight, Earl Howe Parliamentary Under Secretary to the
Department of Health, Mr Cameron Prime Minister of Great Britain
and Northern Ireland,

I am writing to thank the HPA for the response which I received to
my FOI Request about the toxicity of Clozapine Ref: 12/01/03/nc/001
Health Protection Agency

www.hpa.org.uk

"24 February 2012
Dear Ms [last name removed]

Re: Internal review for National Poisons Information Service

Thank you for your email of the 2 February 2012 in which you
requested an internal review of our response to your Freedom of
Information request regarding National Poisons Information Service.
........

My findings are as below are set out below.
Health Protection Agency (HPA) informed Ms [last name removed] that
in relation to her request for information regarding the toxicology
reports on Zaponex and Clozapine was exempt from disclosure under
section 21, of the Freedom of Information Act (FoI) which exempts
information if the information is reasonable accessible to the
applicant by other means.

Section 21 is a qualified exemption which means that information
can only be disclosed if the public interest in favour of
withholding the information outweighs the public interest in
releasing the information.

HPA outlined in its response the arguments for not disclosing the
requested information. The information requested is already in the
public domain. All prescribed medicine comes with accompanying
inserts which contain information about the medication and any
known adverse health effects.

HPA should have also applied section 38 (1) (a) of the FoI Act.
Section 38 (1) (a) exempts information if disclosure would endanger
the physical or mental health of any individual.

The arguments in favour of disclosing the information turn upon the
very real public interest that exist regarding he work of the HPA
and the need for transparency. HPA acknowledge that releasing this
information would inform and educate the public about the work HPA
implements.

The arguments against disclosure are concerned with the health and
safety of individuals, who would use the information to harm
themselves. I understand in our letter of 30 January to you, HPA
clarified that medication taken in combustion with other medication
can be toxic/poisonous. Unstable individuals could use this
information to harm themselves. HPA clarified to Ms [last name
removed] that information the National Poisons Information Service
TOXBASE is used to advise medical staff and could be misinterpreted
by the public.

I have careful considered of the above public interest arguments I
conclude the public interest in withholding the requested
information outweighs that favouring release and I am content the
material requested is exempt from disclosure under sections 21 and
38 (1) (a) FoI Act.

This completes the internal review process at the Health Protection
Agency."

I would like to respond by saying that whilst it is certainly fact
that there ARE documents on the toxicology of Clozapine, and I have
seen them, my specific question was the information that is being
withheld from public view is the very information that is NOT
publicly accessible by any other means.

What clearly worries the HPA is that if the public get to see a
report on Clozapine that might damage the faith of the public in
such a product.

However, this has, de facto, been agreed to be a toxic substance
and I have found a health trust specifically stating that COSHH
guidelines govern the safety of hazardous substances, and name
Clozapine as such a hazardous substance.

What is it that makes Clozapine a COSHH hazard?

As I understood it, the toxicity of Clozapine was merely that it
could be related to a cause of death as per the Coroner's Decision
in December 2011 re Catherine Bell.

I did not realise that it could affect anyone as a hazardous
substance in its own right. Please may I request that if you have
ANY information as to it being a COSHH hazard that you inform us as
a matter of right to know. And if it is not a COSHH hazard why has
a health trust stated it has to be considered under this regulation
for Safety? It makes no sense to me if the chemicals are harmless
in themselves.

Thank you very much for your help

Yours sincerely,

[first name removed] [last name removed]

Campaigner for legal reform of ALL the Mental Health legislation in
England
Campaigner for liberty, truth and justice

Link to this
From: Freedom Of Information
Health Protection Agency

1 March 2012
Dear Ms [last name removed]

The Freedom of Information team acknowledges your request for
information regarding COSHH. You will receive a response within 20
working days.

Kind regards

Freedom of Information Officer.

show quoted sections

Link to this
From: Freedom Of Information
Health Protection Agency

22 March 2012
Dear Ms [last name removed]

Thank you for your further emails regarding Clozapine.

In the internal review letter to your question regarding Clozapine,
we explained the HPA does not hold the information you require.
This information is not held, because the HPA does not carry out
testing on Clozapine.

I regret we are unable to assist you with your questions on
Clozapine, however I would advise you to contact the Medicines
Healthcare Products Regulatory Agency (MHCPRA) or the European
Licensing/Regulatory Authority. These organisations may be able to
aid you with your query.

For further information you can contact MHCPRA at [email address]

Kind Regards

Gloria Akinyemi

show quoted sections

Link to this
From: [first name removed] [last name removed]

22 March 2012
22 March 2012

Dear Health Protection Agency, MHRA, Department of Health, Health
and Safety Executive - COSHH, Secretary of State for Health,
Medical Research Council, Mr Turner MP for the Isle of Wight, Mr
Cameron Prime Minister of Great Britain and Northern Ireland,

I thank the HPA personnel for giving me a variety of information in
relation to my Freedom of Information Request regarding Clozapine.

What surprises me is that the HPA has admitted that yes, they DO
hold information but that they refuse to release it because the
knowledge might fall into the wrong hands, not because they do not
hold information on Clozapine.

Another reason not to give me information on Clozapine is that it
is stated that the HPA does not do tests on Clozapine. But
previously it was stated that the HPA DOES have information but
they refuse to release information that
a] is available by other means
b] might harm people for this knowledge to become public

=====================================================
The MRC however has produced in 2009 a major document which I only
found out about by chance about 24 hours ago:

http://safety.csc.mrc.ac.uk/docs/coshh/C...

Risk Phrases
R22 R36/37/38
• Harmful if swallowed.
• Irritating to eyes, respiratory system and skin.

Safety Phrases
S26
• In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.

Hazardous Chemical Details
Chemical Form Amount Storage
Clozapine Powder (faintly yellow) 25mg Room temperature, Keep
tightly closed
=====================================================

In this document it specifically states that the yellow powder of
Clozapine is an irritant.

I wish to know just HOW dangerous Clozapine is, for if it irritates
the skin and eyes, surely it has the potential to irritate the
epithelium and cause great harm internally to people who are
possibly FORCED to take this drug if they are under Section 3 of
the Mental Health Act 1983[2007] for example.

Does the HPA liaise with the MRC?

The case of Catherine Bell's death - and the Coroner's Decision in
December 2011 linking her death specifically with Clozapine -
highlights to me this issue.

Is it in the public interest to withhold the TOXBASE materials that
the HPA has?

Clearly you know far more about this toxic substance than you wish
the general public to know. Why is this?

People's lives are potentially being put at risk by such
decision-making by the HPA, I aver, as everyone should be made
privy to the TOXBASE so as to protect and save lives.

I look forward to receiving the information I requested regarding
the HPA's database on Clozapine and its REAL dangers.

Thank you very much for your help.

Yours sincerely,

[first name removed] [last name removed]

Campaigner for legal reform, liberty, truth and justice

Link to this
From: Freedom Of Information
Health Protection Agency

23 March 2012
Dear Ms [last name removed]

Thank you for your email. Your comments have been noted. However,
we have nothing further to add to our response on Clozapine sent to
you on 22nd March.

Kind regards

Freedom of Information Officer

show quoted sections

Link to this
From: [first name removed] [last name removed]

23 March 2012
23 March 2012

Dear Freedom Of Information,National Poisons Agency,HPA, MHRA, Mr
Lansley Secretary of State for Health, Lord Howe Parliamentary
Under Secretary to the Department of Health, Mr Turner MP for the
Isle of Wight,

I thank the HPA for your response. I remain very concerned and then
yesterday I found a specific reference to Clozapine as being a
KNOWN CARCINOGEN:

https://www.cdnisotopes.com/msds/en/D-39...

How can a KNOWN carcinogen be specifically given to people to
ingest?

And how can the HPA be saying it is safe either as a chemical or as
a drug?

And how can the MHRA be saying it is safe as a MEDICINE?

And how can the Department of Health be saying it is safe as a
medicine?

And how can NICE agree to its being given as a medicine?

And what redress do patients have in any given situation where they
have not been informed of the specific dangers of this TOXIC
CHEMICAL THAT IS A KNOWN CARCINOGEN according to CDN ISOTOPES?

I believe that this is a very dangerous chemical and may be a
"Thalidomide" in the making or like the "mattress grade" silicone
used in breast implants.

Please look into this as a matter of great urgency.

Thank you very much,

Yours sincerely,

[first name removed] [last name removed]

Campaigner for legal reform, liberty, truth and justice

Link to this

National Patient Safety Agency

8 April 2012


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Link to this

From: Kumba Jaiteh
National Patient Safety Agency

16 April 2012

Dear [first name removed]

Thank you for your enquiry, this has been passed onto a colleague who will contact you as soon as possible.

Kind regards

Kumba Jaiteh on behalf of Enquiry Line

show quoted sections

Link to this

From: Kumba Jaiteh
National Patient Safety Agency

16 April 2012

Dear [first name removed]

Thank you for your enquiry, sorry for the delay in responding you, this has been passed onto a colleague who will contact you as soon as possible.

Kind regards

Kumba Jaiteh on behalf of Enquiry Line

show quoted sections

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