metastatic Cholangiocarcinoma (CCA) and Acute myeloid leukaemia (AML)

Derbyshire Healthcare NHS Foundation Trust did not have the information requested.

Dear Derbyshire Healthcare NHS Foundation Trust,

Please can I request answers relating to the below questions. A national collation of this information will be made available to any trust requesting it in reply.

1. How many patients in the last 12 months has the trust treated for metastatic Cholangiocarcinoma (CCA) or Acute myeloid leukaemia (AML)?
a. For each of AML and CCA, how many have IDH-1 mutation?
b. How many CCA are intrahepatic vs extrahepatic?
i. How many of each of these present at 2nd line? How many of these at 2nd line have IDH-1 mutation?
c. For AML, how many patients were not fit for intensive chemotherapy? How many of these AML patients have IDH-1 mutation?

2. How many patients have been treated with pemigatinib (CCA), venetoclax plus azacitadine dual therapy or azacitadine monotherapy (AML )?
a. What is the average treatment duration for CCA patients treated with pemigatinib and AML patients treated with azacitadine dual therapy and azacitadine monotherapy? What is the preferred azacitadine product?

3. What is the real-world dosing for venetoclax (in combination with a CYP3A4)?
a. What is the antifungal of choice for patients treated with venetoclax?
b. What is the antifungal average treatment duration when used in combination with venetoclax ?
c) what proportion of patients are treated with an antifungal in combination with venetoclax? In what proportion of patients is the antifungal treatment stopped? In what proportion of these pts is the venetoclax dosage altered following cessation of the antifungal?

4. Do you routinely test CCA and AML patients for IDH-1 mutation?
a. If so when does the testing take place. E.g. at diagnosis or following 1st line progression? Is this done using NGS panel? Is this done using PCR testing?
B. What is the average turnaround time for these tests?

5. Who is responsible for the routine management of patients with CCA and AML?
a. Clinical oncologist / medical oncologist / specialist nurse etc?

6. How many admissions have occurred in the last 12 months for patients with CCA and AML?
a. What is their average length of stay?
b. How many of these patients were readmissions or readmitted during this time? If readmitted, can you state the main reason?

Thank you for taking the time to supply this information.

Yours faithfully,

Oliver Caswell

FOIEnquiries (DERBYSHIRE HEALTHCARE NHS FOUNDATION TRUST), Derbyshire Healthcare NHS Foundation Trust

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Freedom of Information Office

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The Ashbourne Centre

Kingsway Site

Kingsway

Derby DE22 3LZ

Tel 01332 623700

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FOIEnquiries (DERBYSHIRE HEALTHCARE NHS FOUNDATION TRUST), Derbyshire Healthcare NHS Foundation Trust

Dear Oliver

Thank you for your request for information under the Freedom of Information Act 2000.

The Trust is commissioned to provide mental health services and as such does not have the information requested. Your request may be best served directed towards the University Hospitals of Derby and Burton and / or Chesterfield Royal Hospital.

If you are unhappy in any way with the way in which your request has been handled, please do not hesitate to contact the FOI enquiries team again in the first instance or, alternatively, the Trust has an internal complaints procedure through which you can raise any concerns you might have. This can be done by writing to the Chief Executive at Ashbourne Centre, Kingsway Site, Kingsway, Derby DE22 3LZ.

If you remain dissatisfied you can apply to the Information Commissioner who will consider whether the Trust has complied with its obligations under the Freedom of Information Act 2000 and can require the Trust to remedy any problems. Information about how to do this can found on the Information Commissioner’s website at www.informationcommissioner.gov.uk. Complaints to the Information Commissioner should be sent to FOI/EIR Complaints Resolution, Information Commissioner’s Office, Wycliffe House, Water Lane, Wilmslow, Cheshire SK9 5AF.

Kind regards.

Freedom of Information Office
Derbyshire Healthcare NHS Foundation Trust

The Ashbourne Centre
Kingsway Site
Kingsway
Derby DE22 3LZ
Tel 01332 623700

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