In vivo proof of concept within the Drug Discovery Unit's Innovative Targets Portfolio (ITP).

Roedd y cais yn llwyddiannus.

SJA Grove (Ataliwyd y cyfrif)

Dear University of Dundee,

The LinkedIn profile of an individual, who is shown to be a University of Dundee School of Life Sciences employee (on the staff directory) and a recipient of The Brian Cox Award for Public Engagement (from the university's own web pages), outlines that their work has shown that they have demonstrated "in vivo proof of concept" for a project within the Innovative Targets Portfolio (ITP) that was the "portfolio's key project". This will, no doubt, be one of the many successes of the ITP that has led to the formation of companies such as In4derm. Not only did this employee demonstrate the in vivo proof of concept of this project but it was done whilst the "team leader" was off sick for two years and they were "deputising".

Which member(s) of the School of Life Sciences staff formally manage(s) the Innovative Targets Portfolio (ITP) within the Drug Discovery Unit of the Division of Biological Chemistry and Drug Discovery of the School of Life Sciences in the years 2012 to present?

Which year did the Drug Discovery Unit (DDU) demonstrate IN VIVO proof of concept for their "portfolio's key project" within the ITP?

Assuming that proof of concept (PoC) in cells is demonstrated prior to PoC in vivo (for both logical and ethical reasons) which year did the Dundee Drug Discovery Unit demonstrate proof of concept in cells (i.e. in vitro) for the "portfolio's key project"?

How many biology targets with the Drug Discovery Unit ITP have reached the DDU/BCDD criteria of in vivo proof of concept?

How many of the biology targets with the Drug Discovery Unit ITP have reached the DDU/BCDD criteria of in vivo proof of concept were successes of the DDU in isolation and how many were in vivo PoCs taken from the external literature?

What is the University of Dundee's policy of forbidding staff to report personal matters (e.g. the sickness absence) of other University of Dundee staff on social media such as Twitter and LinkedIn, and when was this policy and procedure introduced?

Yours faithfully,
SJA Grove

FreedomOfInformation, University of Dundee

Thank you for your email.  If your message contains a request for
information the University will respond no later than 20 working days from
its receipt (or one month from receipt in the case of requests for your
own personal information).

If you have any questions about how your request will be managed, please
let me know.

Kind regards,

Alan Bell

Head of Information Governance

University of Dundee

Dundee DD1 4HN

The University of Dundee is a registered Scottish Charity, No: SC015096

FreedomOfInformation, University of Dundee

Dear SJA Grove,

Thank you for your request for information from the University of Dundee. Colleagues provide answers to your questions below.

1. Which member(s) of the School of Life Sciences staff formally manage(s) the Innovative Targets Portfolio (ITP) within the Drug Discovery Unit of the Division of Biological Chemistry and Drug Discovery of the School of Life Sciences in the years 2012 to present?

Professor P Wyatt, Professor M Ferguson, Dr J Brady, Dr D Gray, Dr A Woodland.

2. Which year did the Drug Discovery Unit (DDU) demonstrate IN VIVO proof of concept for their "portfolio's key project" within the ITP?
3. Assuming that proof of concept (PoC) in cells is demonstrated prior to PoC in vivo (for both logical and ethical reasons) which year did the Dundee Drug Discovery Unit demonstrate proof of concept in cells (i.e. in vitro) for the "portfolio's key project"?

Without further context we are unsure of which project you mean. If you could provide more information, I will pass that to colleagues for their consideration.

4. How many biology targets with the Drug Discovery Unit ITP have reached the DDU/BCDD criteria of in vivo proof of concept?

Two since 2012.

5. How many of the biology targets with the Drug Discovery Unit ITP have reached the DDU/BCDD criteria of in vivo proof of concept were successes of the DDU in isolation…

Zero. Colleagues note that they do not internalise the primary biology so always work in collaboration with expert biologists outside the DDU.

6. and how many were in vivo PoCs taken from the external literature?

Zero. Colleagues confirm that they seek to validate using their own chemical matter.

7. What is the University of Dundee's policy of forbidding staff to report personal matters (e.g. the sickness absence) of other University of Dundee staff on social media such as Twitter and LinkedIn, and when was this policy and procedure introduced?

The University’s social networking policy is online here - https://uod.app.box.com/s/305u21o5kcjaop.... For information on data protection at the University please see https://www.dundee.ac.uk/information-gov....

I trust that this information is helpful.

Kind regards,

Alan

--
Alan Bell
Head of Information Governance
Culture & Information
University of Dundee
Dundee DD1 4HN

t: 01382 384441
http://www.dundee.ac.uk/cultureandinform...

This email is not legal advice and should not be
considered in that way.

Should you wish to appeal any decision concerning
the release of information by the University please
respond to [University of Dundee request email].
The University will then review your appeal according
to the procedures at
http://www.dundee.ac.uk/information-gove...

If you are unhappy with the outcome of that review please forward your appeal to the Scottish Information Commissioner, Kinburn Castle, Doubledykes Rd, St Andrews, Fife, KY16 9DS (www.itspublicknowledge.info/Appeal).

If you remain dissatisfied following an appeal to the Commissioner your recourse is to the Court of Session on a point of law.

dangos adrannau a ddyfynnir

Dear University of Dundee,

The LinkedIn profile of an individual, who is shown to be a University of Dundee School of Life Sciences employee (on the staff directory) and a recipient of The Brian Cox Award for Public Engagement (from the university's own web pages), outlines that their work has shown that they have demonstrated "in vivo proof of concept" for a project within the Innovative Targets Portfolio (ITP) that was the "portfolio's key project". This will, no doubt, be one of the many successes of the ITP that has led to the formation of companies such as In4derm. Not only did this employee demonstrate the in vivo proof of concept of this project but it was done whilst the "team leader" was off sick for two years and they were "deputising".

Which member(s) of the School of Life Sciences staff formally manage(s) the Innovative Targets Portfolio (ITP) within the Drug Discovery Unit of the Division of Biological Chemistry and Drug Discovery of the School of Life Sciences in the years 2012 to present?

Which year did the Drug Discovery Unit (DDU) demonstrate IN VIVO proof of concept for their "portfolio's key project" within the ITP?

Assuming that proof of concept (PoC) in cells is demonstrated prior to PoC in vivo (for both logical and ethical reasons) which year did the Dundee Drug Discovery Unit demonstrate proof of concept in cells (i.e. in vitro) for the "portfolio's key project"?

How many biology targets with the Drug Discovery Unit ITP have reached the DDU/BCDD criteria of in vivo proof of concept?

How many of the biology targets with the Drug Discovery Unit ITP have reached the DDU/BCDD criteria of in vivo proof of concept were successes of the DDU in isolation and how many were in vivo PoCs taken from the external literature?

What is the University of Dundee's policy of forbidding staff to report personal matters (e.g. the sickness absence) of other University of Dundee staff on social media such as Twitter and LinkedIn, and when was this policy and procedure introduced?

Yours faithfully,
SJA Grove

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The University of Dundee is a registered Scottish Charity, No: SC015096

SJA Grove (Ataliwyd y cyfrif)

Dear FreedomOfInformation,

The information kindly provided by the UoD differs from the information that is disclosed in the Innovative Targets Portfolio chart on the DDU's own webpages. Please answer questions 2 and 3 based on the "portfolio's key project" being the only one that has passed the "To PoC in cells" criteria with the project being defined as being "Inflammation, RA" and is being worked on in conjunction with a UoD collaborator (i.e. not an external group).
Thankyou in anticipation.

Yours sincerely,

SJA Grove

FreedomOfInformation, University of Dundee

Thank you for your email.  If your message contains a request for
information the University will respond no later than 20 working days from
its receipt (or one month from receipt in the case of requests for your
own personal information).

If you have any questions about how your request will be managed, please
let me know.

Kind regards,

Alan Bell

Head of Information Governance

University of Dundee

Dundee DD1 4HN

The University of Dundee is a registered Scottish Charity, No: SC015096

FreedomOfInformation, University of Dundee

Dear SJA Grove,

Thank you for your clarification. Please find answers to your outstanding questions below.

2. Which year did the Drug Discovery Unit (DDU) demonstrate IN VIVO proof of concept for their "portfolio's key project" within the ITP?

2018

3. Assuming that proof of concept (PoC) in cells is demonstrated prior to PoC in vivo (for both logical and ethical reasons) which year did the Dundee Drug Discovery Unit demonstrate proof of concept in cells (i.e. in vitro) for the "portfolio's key project"?

2014

I trust that this information is helpful.

Kind regards,

Alan

--
Alan Bell
Head of Information Governance
Culture & Information
University of Dundee
Dundee DD1 4HN

t: 01382 384441
http://www.dundee.ac.uk/cultureandinform...

This email is not legal advice and should not be
considered in that way.

Should you wish to appeal any decision concerning
the release of information by the University please
respond to [University of Dundee request email].
The University will then review your appeal according
to the procedures at
http://www.dundee.ac.uk/information-gove...

If you are unhappy with the outcome of that review please forward your appeal to the Scottish Information Commissioner, Kinburn Castle, Doubledykes Rd, St Andrews, Fife, KY16 9DS (www.itspublicknowledge.info/Appeal).

If you remain dissatisfied following an appeal to the Commissioner your recourse is to the Court of Session on a point of law.

dangos adrannau a ddyfynnir

Dear FreedomOfInformation,

The information kindly provided by the UoD differs from the information that is disclosed in the Innovative Targets Portfolio chart on the DDU's own webpages. Please answer questions 2 and 3 based on the "portfolio's key project" being the only one that has passed the "To PoC in cells" criteria with the project being defined as being "Inflammation, RA" and is being worked on in conjunction with a UoD collaborator (i.e. not an external group).
Thankyou in anticipation.

Yours sincerely,

SJA Grove

dangos adrannau a ddyfynnir